Research

Randomized, Placebo-Controlled, Double-Blind Pilot Study of the Antinociceptive Effect of Menaquinone-7 (Vitamin MK-7) in Patients with Peripheral Neuropathy

A recently published randomised double blind placebo controlled study has shown that the supplementation of vitamin MK-7 in patients with diabetes mellitus and/or vitamin B12 deficiency helps to reduce the symptoms of peripheral neuropathy. This is evidenced by the reduction in the scoring system of the Neuropathy Pain score and increase in the serum vitamin MK-7 levels in the treatment group in comparison with the placebo group.

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Randomized Controlled Trial of the Antinociceptive Effect of Menaquinone-7 (MK-7) in Patients with Peripheral Neuropathy

Menaquinone-7 (MK-7) has shown potential benefit in the management of neuropathic pain in diabetic patients and patients with vitamin B12 deficiency.

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Vitamin K Insufficiency in an India Population: A Pilot Study

The staple, commonly consumed Indian foods showed undetectable content of vitamin K2,suggesting that the general population could benefit from the consumption of vitamin K2 in the form of MK-7 supplements.

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Vitamin K2-7, a promising solution to peripheral neuropathy aroused due to multiple myeloma treatment

Vitamin K2-7 has an ameliorative potential for relief of iatrogenic peripheral neuropathy in multiple myeloma patients.

Bhave AA, Mehta DS, Dound YA, et al. Vitamin K2-7, a Promising Solution to Peripheral Neuropathy aroused due to Multiple Myeloma Treatment. The Indian practitioner.2019; 72 (1):16-20.

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A novel potential role of Vitamin K2-7 in relieving peripheral neuropathy

Vitamin K2-7 has a potential to relief symptoms of peripheral neuropathy due to Vitamin B12 Deficiency or type 2 diabetes mellitus.

Mehta DS, Dound YA, Jadhav SS, et al. A Novel Potential Role of Vitamin K2-7 in Relieving Peripheral Neuropathy. Journal of Pharmacology and Pharmacotherapeutics.2018; 4 (9):180-185.

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Inhibition of TNF-α, IL-1α, and IL-1β by pretreatment of Human Monocyte-Derived Macrophages with Menaquinone-7 and cell activation with TLR agonists in vitro

30 hours pre-treatment of cell culture of human monocyte-derived macrophages (hMDMs) with the natural vitamin K2-menaquinone-7 modulates the immune and inflammatory reactions in the dose-response inhibition of TNF-a, IL-1a, and IL-1b gene expression and protein production by the healthy hMDMs in vitro.

Pan MH, Maresz K, Lee PS. Inhibition of TNF-α, IL-1α, and IL-1β by Pretreatment of Human Monocyte-Derived Macrophages with Menaquinone-7 and Cell Activation with TLR Agonists In Vitro. J Med Food.2016;19(7):663-9.

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Safety assessment of menaquinone-7 for use in human nutrition

Safety assessment of menaquinone-7 for use in human nutrition showed that oral administration of menaquinone-7, at a concentration of 2000 mg/kg, did not cause any acute, subacute and geno toxicity in rats.

Ravishankar B, Dound YA, Mehta DS, et al. Safety assessment of menaquinone-7 for use in human nutrition. J Food Drug Anal. 2015;23(1):99-108.

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The effect of vitamin K2-7 in peripheral neuropathy due to Vitamin B12 deficiency and/or diabetes mellitus: A Preliminary Study

Vitamin K2-7 supplementation at a dose of 100 µg twice a day for 8 weeks has shown relief in symptoms of peripheral neuropathy in patients with megaloblastic anaemia and diabetes mellitus.

Kulkarni VK, Upase DP, Dound YA, et al. The effect of vitamin K2-7 in peripheral neuropathy due to Vitamin B12 deficiency and/or diabetes mellitus: A Preliminary Study. The Indian Practitioner. 2013; 66 (10):625-629.

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Clinical practice guidelines on postmenopausal osteoporosis: An executive summary and recommendations

Clinical practice guidelines from Indian menopausal society recommended supplementation of 180-350 µg/day of vitamin K2-7 along with recommended to intake of calcium, magnesium, vitamin D, and a balanced diet to women at postmenopausal age to benefit bone health and cardiovascular health of women with osteoporosis.

Harinarayan CV, Marwah R, Sahay R, et al. Clinical practice guidelines on postmenopausal osteoporosis: An executive summary and recommendations. J Midlife Health. 2013 ;4(2):107-26.

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Therapeutic activity and safety of vitamin K2-7 in muscle cramps: An interventional case- series

Vitamin K2-7 supplementation at a dose of 100 µg/day for has proven benefits in reduction in frequency of muscle cramps.

Mehta DS, Vaidya RA, Dound YA, et al. Therapeutic Activity and Safety of Vitamin K2-7 in Muscle Cramps: An Interventional Case- Series. The Ind. Pract. 2010; 63(5):287-291

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WATER-SOLUBLE VITAMIN K2 (MK7) INGREDIENT EASES FORMULATION

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VITAMIN K2-7 WITH EXTENDED STABILITY.

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